Endocrine Abstracts

Sunitinib (SU11248) is a multitarget inhibitor of tyrosine-kinases (RTK) recently tested in clinical trials for the treatment of some human cancers. Side effects are mostly represented by asthenia and appear in a dose and time correlated manner. After the unexpected observation of a myxedematous coma in a patient affected with GIST and treated with Sunitinib, we evaluated the effect of this drug on thyroid function in 24 patients treated for GISTs Imatinib resistant. Patients ...

Background: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic disease (Covid-19) affects thyroid function with different mechanisms: non-thyroidal illness syndrome (NTIS), direct infection of thyroid gland and cytokine storm. We provided the first description of painless atypical thyroiditis coexisting with NTIS in patients hospitalised for moderate-to-severe Covid-19 disease. We aimed to: 1) correlate thyroid dysfunction with Covid-19 disease severity;...

BackgroundWe provided the first description of thyrotoxicosis due to atypical thyroiditis in patients hospitalised for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19), not associated with neck pain, more common in men, correlated with disease severity and coexisting with non-thyroidal illness syndrome. Classic viral subacute thyroiditis is often followed by permanent thyroid dysfunction and autoimmunity, thus we h...